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BioInformatics, Genetics
Genetic Engineering:
The technique of removing, modifying, or adding genes to a DNA molecule in order to change the information it contains. By changing this information, genetic engineering changes the type or amount of proteins an organism is capable of producing, thus enabling it to make new substances or perform new functions.
From: usinfo.state.gov/journals/ites/0903/ijee/glossary.htm
A broad term to describe applications of computer technology and information science to organize, interpret, and predict biological structure and function. Bioinformatics is ususally applied in the context of analyzing DNA sequence data.
From : www.plpa.agri.umn.edu/scag1500/definitions.html
Microarray
A technology using a high-density array of nucleic acids, protein, or tissue for examining complex biological interactions simultaneously which are identified by specific location on a slide array. A scanning microscope detects the bound, labeled sample and measures the visualized probe to ascertain the activity of the genes of interest in genotyping, cellular studies, and expression analysis.
From : www.qdots.com/live/render/content.asp
MAPMAKER/EXP
Platform : Win 32, Unix like, Mac OSX
License : Open Source, Free for Non Commercial Use
Appears in these categories : BioInformatics, Genetics
License : Open Source, Free for Non Commercial Use
Appears in these categories : BioInformatics, Genetics
MAPMAKER/EXP is a linkage analysis package designed to help construct primary
linkage maps of markers segregating in experimental crosses. MAPMAKER/EXP
performs full multipoint linkage analysis (simultaneous estimation of all
recombination fractions from the primary data) for dominant, recessive, and co-
dominant (e.g. RFLP-like) markers. MAPMAKER/EXP is an experimental-cross-only
successor to the original MAPMAKER program.
MAPMAKER/QTL is a companion program to MAPMAKER/EXP which allows one to map
genes controlling polygenic quantitative traits in F2 intercrosses and BC1
backcrosses relative to a genetic linkage map. More information on MAPMAKER/QTL
can be found in the technical report (included with MAPMAKER/QTL).
New features in this release include:
- Many many bug-fixes, feature, and user-interface improvements.
- A sophisticated algorithm for detecting typing errors in data from
experimental crosses (see Lincoln and Lander, "Systematic Detection of Errors
in Genetic Linkage Data" Genomics 14: 604-610)
- The ability to draw genetic maps (in MAPMAKER/EXP) and LOD-score plots (in
MAPMAKER/QTL) as PostScript files.
- Support for additional cross types, including F2 intercross, BC1 backcross,
F3(self) intercross, and sib and self mated Recombinant Inbreds in
MAPMAKER/EXP.
- Many features for automating analysis and storing results, particularly
useful with very large data sets. An outline of a database interface is
provided, for sites who wish to integrate MAPMAKER into their informatics
systems.
- New "three point" and "join haplotypes" features for speeding lengthy
analyses.
- A new license agreement which allows free redistribution of MAPMAKER.Under
specific conditions, you may even distribute modified versions of MAPMAKER.
linkage maps of markers segregating in experimental crosses. MAPMAKER/EXP
performs full multipoint linkage analysis (simultaneous estimation of all
recombination fractions from the primary data) for dominant, recessive, and co-
dominant (e.g. RFLP-like) markers. MAPMAKER/EXP is an experimental-cross-only
successor to the original MAPMAKER program.
MAPMAKER/QTL is a companion program to MAPMAKER/EXP which allows one to map
genes controlling polygenic quantitative traits in F2 intercrosses and BC1
backcrosses relative to a genetic linkage map. More information on MAPMAKER/QTL
can be found in the technical report (included with MAPMAKER/QTL).
New features in this release include:
- Many many bug-fixes, feature, and user-interface improvements.
- A sophisticated algorithm for detecting typing errors in data from
experimental crosses (see Lincoln and Lander, "Systematic Detection of Errors
in Genetic Linkage Data" Genomics 14: 604-610)
- The ability to draw genetic maps (in MAPMAKER/EXP) and LOD-score plots (in
MAPMAKER/QTL) as PostScript files.
- Support for additional cross types, including F2 intercross, BC1 backcross,
F3(self) intercross, and sib and self mated Recombinant Inbreds in
MAPMAKER/EXP.
- Many features for automating analysis and storing results, particularly
useful with very large data sets. An outline of a database interface is
provided, for sites who wish to integrate MAPMAKER into their informatics
systems.
- New "three point" and "join haplotypes" features for speeding lengthy
analyses.
- A new license agreement which allows free redistribution of MAPMAKER.Under
specific conditions, you may even distribute modified versions of MAPMAKER.
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